i-PRF-Skin-Rejuvenation-and-Hair-Growth-Dundalk

Introduction

Injectable Platelet-Rich Fibrin (i-PRF) is the advanced, second-generation evolution of Platelet-Rich Plasma (PRP). This 100% natural, autologous treatment harnesses your body’s own healing powers to rejuvenate skin and stimulate hair growth. Unlike solid PRF, i-PRF remains in a liquid form (liquid PRF), allowing for versatile injection techniques to target various aesthetic concerns.

• 100% Natural: No additives or chemicals.

• Autologous: Derived from your own blood, ensuring biocompatibility and safety.

• Holistic: Stimulates natural regeneration for subtle, long-lasting results.

i-PRF vs PRP: Key Differences

i-PRF surpasses traditional PRP with superior cell concentration and prolonged growth factor release, enhancing tissue regeneration.

Feature	i-PRF	PRP
Additives	100% natural, no additives[¹]	Contains anticoagulants
Centrifugation	Soft spin (lower speed)	Hard spin (higher speed)
Platelet Count	Higher concentration[²]	Lower concentration
Components	Platelets, leukocytes, mesenchymal stem cells, fibrin mesh[¹]	Platelets, some growth factors
Release Time	7–10 days	Hours

[1] Miron, R.J., & Wang, X. (2019). Fluid PRF (iPRF) Stimulates Greater Dermal Skin Fibroblast Than PRP. Journal of Cosmetic Dermatology. [2] Woolley, A. (2020). iPRF Yields Higher Platelet Count Than PRP. Sheffield Teaching Hospitals NHS Foundation Trust.

How Does i-PRF Work?

i-PRF is prepared by drawing a small amount of your blood, which is then spun in a centrifuge at low speed to concentrate platelets, leukocytes, and mesenchymal stem cells within a fibrin mesh. This cell-rich network is injected into targeted areas, where it:

• Releases seven key growth factors (e.g., PDGF, VEGF, EGF) over 7–10 days, promoting tissue repair and regeneration.

• Stimulates collagen and elastin production for skin rejuvenation.

• Enhances hair follicle activity for hair regrowth in early-stage hair loss.

• Supports wound healing and tissue regeneration through leukocyte activity [3].

[3]: Naik, B., et al. (2013). Role of Platelet-Rich Fibrin in Wound Healing.

Benefits

✅ 100% Natural: No chemicals or synthetic additives.

✅ Safe and Autologous: Zero risk of allergic reactions or vascular complications.

✅ Enhanced Regeneration: Higher platelet and leukocyte count for superior results [1].

✅ Long-Lasting Effects: Fibrin mesh ensures prolonged growth factor release.

✅ Versatile: Suitable for multiple skin layers and hair restoration.

✅ Ideal for Sensitivities: Safe for patients allergic to hyaluronidase or with autoimmune disorders.

✅ Minimal Downtime: Subtle, natural results with low risk of side effects.

Indications

i-PRF is a versatile, natural solution for aesthetic concerns, addressing:

Skin Rejuvenation:

• Face, neck, décolleté, hands

• Fine lines and wrinkles

• Tear troughs (dark under-eye circles)

• Nasolabial folds (nose-to-mouth lines)

• Marionette lines (below mouth corners)

• Smokers’ lines (‘barcode’ above lips)

• Stretch marks and acne scars

Hair Restoration:

• Thinning hair in early-stage hair loss (men and women)

• Stimulates dormant hair follicles [4]

[4]: Karimi, K., & Rockwell, H. (2020). Platelet-Rich Fibrin (PRF) for Hair Loss.

Treatment Protocol

Skin Rejuvenation

🔹 Course: 3 sessions, 4–6 weeks apart.

🔹 Maintenance: Every 9–12 months (patient-dependent).

🔹 Procedure: Injected superficially (via Meso Injector or micro needling) or deeper (via needles/cannula), ~1 hour.

🔹 Results: Visible from 4 weeks, improving over 3–6 months.

Hair Restoration

🔹 Course: 6 sessions, 4–6 weeks apart.

🔹 Maintenance: Every 3–6 months.

🔹 Procedure: Targeted injections to scalp, ~1 hour.

🔹 Results: Visible improvements after 3–6 months.

Potential Side Effects

• Minimal swelling, bruising, redness, or itching at injection site (up to 3 days)

• Bruising at venipuncture site

• Light headache

• Extremely rare: Secondary skin infections, nerve/muscle injury

Results and Longevity

• Results: Noticeable from ~4 weeks, with continued improvement in skin texture and tone over 3–6 months.

• Longevity: Up to 18 months, depending on the patient [2].

Contraindications▼

Not suitable for under 18s, pregnant, or breastfeeding women.
No history of skin cancer or active cancer treatment at treatment site.
No anticoagulation therapy or blood disorders (e.g., thrombocytopenia, severe coagulopathies).
No active skin infections or dermatological conditions (e.g., eczema, psoriasis) at treatment site.
No severe metabolic or systemic disorders (e.g., uncontrolled diabetes).
No allergy to local anaesthetics (topical or injectable, e.g., lidocaine, articaine).
No known allergy to treatment components (e.g., plasma derivatives, saline).
No history of keloid scarring.
No active systemic infections (e.g., hepatitis, HIV).

Pre-Treatment Advice▼

Avoid blood thinners (e.g., aspirin, ibuprofen), alcohol, supplements (e.g., fish oils, vitamins A–E) for 72 hours prior to ensure optimal platelet function.
No systemic steroids (e.g., prednisone) for 3 weeks prior.
No dental treatments, aesthetic treatments, or vaccines 2 weeks prior.
Avoid retinol or retinoid products (e.g., tretinoin, adapalene) for 5 days prior to reduce skin irritation.
Ensure no active infections; consult a doctor if recent illness is suspected.

Post-Treatment Advice▼

Avoid massaging or pressuring treated areas for 48 hours.
Avoid heat (e.g., hot showers, saunas, sun, intense exercise) for 48 hours to minimize swelling/bruising.
No alcohol for 48 hours.
No aesthetic treatments, vaccines, or dental treatments for 2 weeks post-treatment.
Avoid retinol or retinoid products (e.g., tretinoin, adapalene) for 5 days post-treatment to support healing.
Avoid makeup for 24 hours; use gentle skincare (no acids, AHAs) for 48 hours.
Avoid washing treated area for 24 hours to allow growth factors or plasma components to settle.
Monitor for signs of infection (e.g., redness, swelling, pain) and contact practitioner if present.

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