XoRP - dk-medicalaesthetics.ie

Introduction

XoRP is a cutting-edge autologous injectable treatment that uses exosome rich plasma derived from your own blood through ultrafiltration and ultracentrifugation. These nano-sized extracellular vesicles (30–150 nm - around 1/1000 the width of a human hair) deliver powerful biological signals that support skin regeneration and hair follicle stimulation.

As one of the leading trends in regenerative aesthetics, XoRP is fully injectable and safe, unlike exosomes derived from non-human or donor human sources, which may carry foreign genetic micro-particles and are restricted to topical use. No animal, plant, or donor-human components are used - only your own biology.

How many exosomes per mL?

Source	Claimed Exosome Count
Autologous (platelet-derived)	~20–25 billion/mL (manufacturer data)
Human-derived (umbilical/placenta)	~50–250 billion per vial (unverified)
Plant-derived	~1–10 billion/mL (unverified)
Bovine colostrum-derived	~4 billion/mL (unverified)

⚠️ All values are manufacturer reported, not independently verified - often representing total vesicle count rather than exosomes alone.
❗ Although autologous numbers seem lower, they are significantly more biocompatible and injectable, without risk of foreign immune response.

Benefits

✅ Activates cellular repair and regeneration
✅ Increases collagen and elastin synthesis
✅ Enhances scalp health and supports hair growth
✅ Fully injectable - using only patient’s own cells
✅ Low risk of adverse reactions
✅ Highly potent and precise skin and tissue rejuvenation

Indications

Skin: aging, dullness, uneven texture, photo damage
Scalp: early thinning, low circulation, decreased density
Recovery: after microneedling, laser, or acid treatments
Maintenance: between regenerative treatments
Minor scarring or post-inflammatory skin changes

Treatment Protocol

🔷 Skin: 2 sessions, 3 – 4 weeks apart
🔷 Scalp: 2 – 3 sessions, 3 – 4 weeks apart
🔷 Maintenance: Skin every 4 – 6 months; Scalp every 3 – 4 months
🔷 Full procedure time: approx. 60 minutes, including blood draw, preparation, and treatment
🔷 Each session yields approx. 4 – 5 mL of exosome-rich plasma - sufficient for either the face & neck or scalp, not both
🔷 Results develop progressively over 1 – 3 months through your body’s natural response

Downtime & Safety

Minimal downtime - most resume daily activities same day
Mild redness or swelling may last 24 – 48 hours
Light bruising possible at draw or injection sites
Autologous = very low risk of reaction or immune incompatibility

📚 References & Evidence

Kalinec, G. M., et al. (2023). Platelet-derived extracellular vesicles in regenerative medicine: Mechanisms and clinical applications. Journal of Translational Medicine.
T‑Lab (Exomine Kit): Manufacturer data confirms ~20–25 billion autologous exosomes/mL via ultrafiltration & ultracentrifugation.
Purasomes (colostrum-derived): ~4 billion/mL (manufacturer data).
Filcore P198 (umbilical-derived, UK): ~50–250 billion per vial (manufacturer data, not per mL).

Contraindications▼

Not suitable for under 18s, pregnant, or breastfeeding women.
No history of skin cancer or active cancer treatment at treatment site.
No anticoagulation therapy or blood disorders (e.g., thrombocytopenia, severe coagulopathies).
No active skin infections or dermatological conditions (e.g., eczema, psoriasis) at treatment site.
No severe metabolic or systemic disorders (e.g., uncontrolled diabetes).
No allergy to local anaesthetics (topical or injectable, e.g., lidocaine, articaine).
No known allergy to treatment components (e.g., plasma derivatives, saline).
No history of keloid scarring.
No active systemic infections (e.g., hepatitis, HIV).

Pre-Treatment Advice▼

Avoid blood thinners (e.g., aspirin, ibuprofen), alcohol, supplements (e.g., fish oils, vitamins A–E) for 72 hours prior to ensure optimal platelet function.
No systemic steroids (e.g., prednisone) for 3 weeks prior.
No dental treatments, aesthetic treatments, or vaccines 2 weeks prior.
Avoid retinol or retinoid products (e.g., tretinoin, adapalene) for 5 days prior to reduce skin irritation.
Ensure no active infections; consult a doctor if recent illness is suspected.

Post-Treatment Advice▼

Avoid massaging or pressuring treated areas for 48 hours.
Avoid heat (e.g., hot showers, saunas, sun, intense exercise) for 48 hours to minimize swelling/bruising.
No alcohol for 48 hours.
No aesthetic treatments, vaccines, or dental treatments for 2 weeks post-treatment.
Avoid retinol or retinoid products (e.g., tretinoin, adapalene) for 5 days post-treatment to support healing.
Avoid makeup for 24 hours; use gentle skincare (no acids, AHAs) for 48 hours.
Avoid washing treated area for 24 hours to allow growth factors or plasma components to settle.
Monitor for signs of infection (e.g., redness, swelling, pain) and contact practitioner if present.

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